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Intravenous iron sucrose reverses anemia-induced cardiac remodeling, prevents myocardial fibrosis, and improves cardiac function by attenuating oxidative/nitrosative stress and inflammation
(Elsevier Ireland, 2016-06)
Background: According to recent clinical trial data, correction of iron deficiency with intravenous (i.v.) iron has favorable outcomes on cardiac function. We evaluated whether i.v. iron treatment of anemic rats has favorable ...
Regulation of the Cardiac Sodium/Bicarbonate cotransporter by Angiotensin II: potential contribution to structural, ionic and electrophysiological Myocardial remodelling
(Bentham Science Publishers, 2013-02)
The sodium/ bicarbonate cotransporter (NBC) is, with the Na+ /H+ exchanger (NHE), an important alkalinizing mechanism that maintains cellular intracellular pH (pHi). In the heart exists at least three isoforms of NBC, one ...
Regulation of intracellular pH is altered in cardiac myocytes of ovariectomized rats
(American Heart Association, Inc, 2019-04-02)
Background-—It is well known that after menopause women are exposed to a greater cardiovascular risk, but the intracellular modifications are not properly described. The sodium/proton exchanger (NHE) and the sodium/bicarbonate ...
The role of the Neuregulin-1/Erbb signaling pathway in cardiac morphogenesis and remodeling
(Sociedad Argentina de Fisiología, 2014-02)
Neuregulin-1 (NRG1) signaling through tyrosine kinase receptors erbB2 and erbB4 was revealed essential for cardiac development as mouse mutated in the Nrg1 or either cognate receptors Erbb2 or Erbb4 genes lack the formation ...
Endogenous osteopontin induces myocardial CCL5 and MMP-2 activation that contributes to inflammation and cardiac remodeling in a mouse model of chronic Chagas heart disease
(Elsevier Science, 2018-01)
Cardiac dysfunction with progressive inflammation and fibrosis is a hallmark of Chagas disease caused by persistent Trypanosoma cruzi infection. Osteopontin (OPN) is a pro-inflammatory cytokine that orchestrates mechanisms ...
Implications of the transcription factor WT1 linked to the pathologic cardiac remodeling post-myocardial infarctionImplicaciones del factor de transcripción WT1 asociado al remodelado cardiaco patológico postinfarto miocárdico
(Elsevier Doyma Sl, 2019-05)
Nuevos avances en el tratamiento del infarto agudo de miocardio involucran inéditas vías de senalización ˜ y progenie celular. En este sentido, la regeneración es una herramienta novedosa que contribuiría al remodelado ...
Silencing of the Na+/H+ exchanger 1(NHE-1) prevents cardiac structural and functional remodeling induced by angiotensin II
(Academic Press Inc Elsevier Science, 2019-04)
Chronic activation of the renin angiotensin system (RAS) favors several cardiac diseases, among which myocardial hypertrophy occupies an outstanding place. In this context, the hyperactivity of the cardiac Na+/H+ (NHE-1) ...
Genetic Deletion of Galectin-3 Altered the Temporal Evolution of Macrophage Infiltration and Healing Affecting the Cardiac Remodeling and Function After Myocardial Infarction in Mice
(American Society of Investigative Pathology, 2020-09)
We studied the role of galectin-3 (Gal-3) in the expression of alternative activation markers (M2) on macrophage, cytokines, and fibrosis through the temporal evolution of healing, ventricular remodeling, and function after ...
High thyrotropin is critical for cardiac electrical remodeling and arrhythmia vulnerability in hypothyroidism
(Mary Ann Liebert, 2019-07-17)
Background: Hypothyroidism, the most common endocrine disease, induces cardiac electrical remodeling that creates a substrate for ventricular arrhythmias. Recent studies report that high thyrotropin (TSH) levels are related ...